BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 1' and Ligand = 'BDBM50007548'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid \| (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned human metabotropic glutamate receptor 1				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid \| (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Parc Club Orsay Universit£ Curated by ChEMBL					Assay Description Binding affinity at Metabotropic glutamate receptor 1				J Med Chem 45: 3171-83 (2002) BindingDB Entry DOI: 10.7270/Q2B27W18
Parc Club Orsay Universit£ Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid \| (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Salerno Curated by ChEMBL					Assay Description Displacement of [3H]Quisqualate from human mGluR1A receptor expressed in BHK cells				Bioorg Med Chem 17: 242-50 (2008) Article DOI: 10.1016/j.bmc.2008.11.015 BindingDB Entry DOI: 10.7270/Q2HD7WKF
Universit£ di Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid \| (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cells				Bioorg Med Chem Lett 16: 196-9 (2005) Article DOI: 10.1016/j.bmcl.2005.09.014 BindingDB Entry DOI: 10.7270/Q2DZ0932
Universit£ di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid \| (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Activity at rat recombinant mGluR1 expressed in CHO cells assessed as intracellular calcium concentration				Bioorg Med Chem 15: 3161-70 (2007) Article DOI: 10.1016/j.bmc.2007.02.040 BindingDB Entry DOI: 10.7270/Q2CN74RR
Universit£ di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid \| (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effect on Metabotropic glutamate receptor 1				J Med Chem 40: 3700-5 (1997) Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid \| (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1c in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
CNS Research Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid \| (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 1 agonist activity as basal [3H]- IP formation in rat				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
Lilly, SA Curated by ChEMBL					More data for this Ligand-Target Pair