BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50017262'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50017262
PNG
(CHEMBL3287714 | US10099993, Compound 63)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)C(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C23H28O7/c1-14(2)21(24)17-8-10-18(15(3)22(17)25)29-11-5-6-12-30-20-13-16(23(26)27)7-9-19(20)28-4/h7-10,13-14,25H,5-6,11-12H2,1-4H3,(H,26,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 116n/an/a7.325



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...

US Patent US10099993 (2018)


BindingDB Entry DOI: 10.7270/Q2Z89FFP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50017262
PNG
(CHEMBL3287714 | US10099993, Compound 63)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)C(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C23H28O7/c1-14(2)21(24)17-8-10-18(15(3)22(17)25)29-11-5-6-12-30-20-13-16(23(26)27)7-9-19(20)28-4/h7-10,13-14,25H,5-6,11-12H2,1-4H3,(H,26,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 116n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...

J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair