Found 10 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50030627' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 334 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by PDSP Ki Database
| |
J Neurochem 71: 2558-64 (1998)
Article DOI: 10.1046/j.1471-4159.1998.71062558.x BindingDB Entry DOI: 10.7270/Q25D8QCZ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by PDSP Ki Database
| |
Annu Rev Pharmacol Toxicol 37: 205-37 (1997)
Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
UPR Centre
Curated by PDSP Ki Database
| |
Mol Pharmacol 50: 923-30 (1996)
BindingDB Entry DOI: 10.7270/Q2M61HS5 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by PDSP Ki Database
| |
Mol Pharmacol 53: 228-33 (1998)
BindingDB Entry DOI: 10.7270/Q2MP51T5 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by PDSP Ki Database
| |
Eur J Pharmacol 267: 77-84 (1994)
Article DOI: 10.1016/0922-4106(94)90227-5 BindingDB Entry DOI: 10.7270/Q2RX99MZ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
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| 5.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Antagonist potency against cloned Metabotropic glutamate receptor 2 |
J Med Chem 43: 2609-45 (2000)
BindingDB Entry DOI: 10.7270/Q2DZ090Q |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| 5.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Antagonist potency against cloned Metabotropic glutamate receptor 2 |
J Med Chem 43: 2609-45 (2000)
BindingDB Entry DOI: 10.7270/Q2DZ090Q |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description Antagonistic activity against mGluR2 was determined |
J Med Chem 39: 2259-69 (1996)
Article DOI: 10.1021/jm960059+ BindingDB Entry DOI: 10.7270/Q2Z60N5G |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 2.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Medical Center
Curated by ChEMBL
| Assay Description Inhibitory concentration required for antagonistic activity at Metabotropic glutamate receptor 2 |
Bioorg Med Chem Lett 11: 1919-24 (2001)
BindingDB Entry DOI: 10.7270/Q2SQ90XH |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030627
((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)Show InChI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 3.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description Ability to inhibit mGluR2-alpha induced cAMP formation was determined at BHK cells at 100 Micro M Concentration |
J Med Chem 38: 3717-9 (1995)
BindingDB Entry DOI: 10.7270/Q2V123TG |
More data for this Ligand-Target Pair | |