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Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50161027'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50161027
PNG
(6-Chloro-5-dimethylamino-pyrazine-2-carboxylic aci...)
Show SMILES CN(C)c1ncc(nc1Cl)C(=O)Nc1ccccn1
Show InChI InChI=1S/C12H12ClN5O/c1-18(2)11-10(13)16-8(7-15-11)12(19)17-9-5-3-4-6-14-9/h3-7H,1-2H3,(H,14,17,19)
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MMDB

KEGG

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PC cid
PC sid
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Article
PubMed
n/an/a 158n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human recombinant metabotropic glutamate receptor 5 (mGlu5) in Ltk cells determined using fluorescence detection met...

Bioorg Med Chem Lett 15: 1197-200 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.078
BindingDB Entry DOI: 10.7270/Q28G8K6P
More data for this
Ligand-Target Pair