Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 8 (Homo sapiens (Human)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8). | J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Perugia Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from rat recombinant mGluR8 expressed in BHK cells by SPA assay | Bioorg Med Chem 15: 3161-70 (2007) Article DOI: 10.1016/j.bmc.2007.02.040 BindingDB Entry DOI: 10.7270/Q2CN74RR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Perugia Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cells | Bioorg Med Chem Lett 16: 196-9 (2005) Article DOI: 10.1016/j.bmcl.2005.09.014 BindingDB Entry DOI: 10.7270/Q2DZ0932 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by PDSP Ki Database | Neuropharmacology 40: 170-7 (2001) Article DOI: 10.1016/s0028-3908(00)00128-3 BindingDB Entry DOI: 10.7270/Q27P8WZ1 | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay | J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Mus musculus) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
CNS Research Curated by ChEMBL | Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR8 in mouse | J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
Universite Paris Descartes Curated by ChEMBL | Assay Description Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ... | J Med Chem 53: 2797-813 (2010) Article DOI: 10.1021/jm901523t BindingDB Entry DOI: 10.7270/Q28W3F7Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a |
Universite Paris Descartes Curated by ChEMBL | Assay Description Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ... | J Med Chem 53: 2797-813 (2010) Article DOI: 10.1021/jm901523t BindingDB Entry DOI: 10.7270/Q28W3F7Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Homo sapiens (Human)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL | Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium... | J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Homo sapiens (Human)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL | Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati... | J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Homo sapiens (Human)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 560 | n/a | n/a | n/a | n/a |
University Paris Descartes Curated by ChEMBL | Assay Description Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production | J Med Chem 50: 3585-95 (2007) Article DOI: 10.1021/jm070262c BindingDB Entry DOI: 10.7270/Q23R0SMQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 128 | n/a | n/a | n/a | n/a |
Université Paris Descartes Curated by ChEMBL | Assay Description Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate production | J Med Chem 50: 4656-64 (2007) Article DOI: 10.1021/jm070400y BindingDB Entry DOI: 10.7270/Q2XP74NQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
Univ. Rouen Curated by ChEMBL | Assay Description Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay | Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Homo sapiens (Human)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Activation of human metabotropic glutamate 8 receptor expressed in golden hamster AV12-664 cells | J Med Chem 61: 10040-10052 (2018) Article DOI: 10.1021/acs.jmedchem.8b01120 BindingDB Entry DOI: 10.7270/Q2SJ1Q0B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Lilly, SA Curated by ChEMBL | Assay Description Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells | J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |