Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM180945'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180945 (US9133187, I-50) Show SMILES C[C@@H](NC(=O)N1Cc2nc(NC3CCOCC3)ncc2C(F)(F)C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C21H23Cl2F2N5O2/c1-12(13-2-3-16(22)17(23)8-13)27-20(31)30-10-18-15(21(24,25)11-30)9-26-19(29-18)28-14-4-6-32-7-5-14/h2-3,8-9,12,14H,4-7,10-11H2,1H3,(H,27,31)(H,26,28,29)/t12-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
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