Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM180948'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180948 (US9133187, I-59) Show SMILES Fc1ccc(cc1Cl)[C@@H](CC#N)NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1 |r| Show InChI InChI=1S/C22H24ClFN6O2/c23-17-11-14(1-2-18(17)24)19(3-7-25)29-22(31)30-8-4-15-12-26-21(28-20(15)13-30)27-16-5-9-32-10-6-16/h1-2,11-12,16,19H,3-6,8-10,13H2,(H,29,31)(H,26,27,28)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
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