Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM204183'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM204183 (US9242996, 257) Show SMILES Nc1ncc(nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(CF)c2)c(F)c1)C1CCOCC1 |r| Show InChI InChI=1S/C25H26F2N4O3/c26-12-15-2-1-3-17(10-15)22(14-32)31-25(33)19-5-4-18(11-20(19)27)23-24(28)29-13-21(30-23)16-6-8-34-9-7-16/h1-5,10-11,13,16,22,32H,6-9,12,14H2,(H2,28,29)(H,31,33)/t22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0197	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG US Patent					Assay Description Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...				US Patent US9242996 (2016) BindingDB Entry DOI: 10.7270/Q2XP73RN
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