Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM13353 (3-fluoro-5-(morpholin-4-yl)-N-{1-[2-(pyridin-4-yl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents | DrugBank MMDB PDB Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of p38alpha kinase | Nat Chem Biol 2: 358-64 (2006) Article DOI: 10.1038/nchembio799 BindingDB Entry DOI: 10.7270/Q2CC10WV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM13353 (3-fluoro-5-(morpholin-4-yl)-N-{1-[2-(pyridin-4-yl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents | DrugBank MMDB PDB Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Astex | Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab... | J Med Chem 48: 414-26 (2005) Article DOI: 10.1021/jm049575n BindingDB Entry DOI: 10.7270/Q26M352S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |