BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM15754'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15754 ((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of p38alpha in hTERT-immortalized human HCA2 cells assessed as decrease in phosphorylated HSP27 level by ELISA in presence of anisomycin				Bioorg Med Chem Lett 18: 3745-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.037 BindingDB Entry DOI: 10.7270/Q2BG2NSG
Cardiff University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15754 ((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of p38alpha-induced TNFalpha production in human THP1 cells				Bioorg Med Chem Lett 18: 3745-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.037 BindingDB Entry DOI: 10.7270/Q2BG2NSG
Cardiff University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15754 ((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of p38alpha (unknown origin)-mediated IL1beta production in peripheral mononucleocytes				Bioorg Med Chem Lett 18: 3745-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.037 BindingDB Entry DOI: 10.7270/Q2BG2NSG
Cardiff University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15754 ((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of p38alpha (unknown origin)-mediated TNFalpha production in peripheral mononucleocytes				Bioorg Med Chem Lett 18: 3745-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.037 BindingDB Entry DOI: 10.7270/Q2BG2NSG
Cardiff University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15754 ((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto LLC					Assay Description Inhibition of human recombinant active p38alpha MAP kinase was tested by measuring the incorporation of 33P from gamma-[33P] ATP into myelin basic pr...				J Med Chem 49: 1562-75 (2006) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q23776ZN
Roche Palo Alto LLC					More data for this Ligand-Target Pair				3D Structure (crystal)