Found 3 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM50175755' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175755
(2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorop...)Show SMILES CC(C)(N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)C(O)=O |(34.29,-15.36,;33.51,-14.03,;32.74,-12.7,;32.18,-14.8,;32.18,-16.34,;30.85,-17.11,;29.51,-16.34,;29.51,-14.8,;30.84,-14.03,;28.18,-17.12,;28.18,-18.67,;26.85,-19.44,;26.85,-20.98,;25.51,-21.74,;25.51,-23.28,;26.85,-24.05,;26.85,-25.59,;28.18,-23.28,;28.18,-21.74,;29.51,-20.97,;25.51,-18.67,;24.18,-19.45,;22.84,-18.67,;22.84,-17.13,;21.51,-16.35,;24.18,-16.36,;24.18,-14.82,;22.85,-14.06,;21.52,-14.83,;22.85,-12.52,;24.19,-11.75,;25.52,-12.52,;25.52,-14.06,;26.85,-14.83,;25.51,-17.12,;26.84,-16.35,;34.84,-13.25,;36.18,-14.01,;34.83,-11.71,)| Show InChI InChI=1S/C30H26Cl3FN2O3/c1-30(2,29(38)39)35-12-10-17(11-13-35)18-14-22(20-7-6-19(34)16-25(20)33)21-8-9-27(37)36(26(21)15-18)28-23(31)4-3-5-24(28)32/h3-9,14-17H,10-13H2,1-2H3,(H,38,39) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.840 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibition of P38 alpha MAPK |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065 BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175755
(2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorop...)Show SMILES CC(C)(N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)C(O)=O |(34.29,-15.36,;33.51,-14.03,;32.74,-12.7,;32.18,-14.8,;32.18,-16.34,;30.85,-17.11,;29.51,-16.34,;29.51,-14.8,;30.84,-14.03,;28.18,-17.12,;28.18,-18.67,;26.85,-19.44,;26.85,-20.98,;25.51,-21.74,;25.51,-23.28,;26.85,-24.05,;26.85,-25.59,;28.18,-23.28,;28.18,-21.74,;29.51,-20.97,;25.51,-18.67,;24.18,-19.45,;22.84,-18.67,;22.84,-17.13,;21.51,-16.35,;24.18,-16.36,;24.18,-14.82,;22.85,-14.06,;21.52,-14.83,;22.85,-12.52,;24.19,-11.75,;25.52,-12.52,;25.52,-14.06,;26.85,-14.83,;25.51,-17.12,;26.84,-16.35,;34.84,-13.25,;36.18,-14.01,;34.83,-11.71,)| Show InChI InChI=1S/C30H26Cl3FN2O3/c1-30(2,29(38)39)35-12-10-17(11-13-35)18-14-22(20-7-6-19(34)16-25(20)33)21-8-9-27(37)36(26(21)15-18)28-23(31)4-3-5-24(28)32/h3-9,14-17H,10-13H2,1-2H3,(H,38,39) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibition of TNF alpha release in THP1 cells |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065 BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175755
(2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorop...)Show SMILES CC(C)(N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)C(O)=O |(34.29,-15.36,;33.51,-14.03,;32.74,-12.7,;32.18,-14.8,;32.18,-16.34,;30.85,-17.11,;29.51,-16.34,;29.51,-14.8,;30.84,-14.03,;28.18,-17.12,;28.18,-18.67,;26.85,-19.44,;26.85,-20.98,;25.51,-21.74,;25.51,-23.28,;26.85,-24.05,;26.85,-25.59,;28.18,-23.28,;28.18,-21.74,;29.51,-20.97,;25.51,-18.67,;24.18,-19.45,;22.84,-18.67,;22.84,-17.13,;21.51,-16.35,;24.18,-16.36,;24.18,-14.82,;22.85,-14.06,;21.52,-14.83,;22.85,-12.52,;24.19,-11.75,;25.52,-12.52,;25.52,-14.06,;26.85,-14.83,;25.51,-17.12,;26.84,-16.35,;34.84,-13.25,;36.18,-14.01,;34.83,-11.71,)| Show InChI InChI=1S/C30H26Cl3FN2O3/c1-30(2,29(38)39)35-12-10-17(11-13-35)18-14-22(20-7-6-19(34)16-25(20)33)21-8-9-27(37)36(26(21)15-18)28-23(31)4-3-5-24(28)32/h3-9,14-17H,10-13H2,1-2H3,(H,38,39) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 79.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibition of LPS stimulated TNF alpha release in whole blood |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065 BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this Ligand-Target Pair | |