Found 3 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM50175756' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175756
(CHEMBL199632 | methyl 2-(4-(5-(2-chloro-4-fluoroph...)Show SMILES COC(=O)C(C)(C)N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(20.15,-17.01,;20.14,-15.47,;18.8,-14.71,;18.79,-13.17,;17.48,-15.49,;18.25,-16.82,;16.7,-14.16,;16.14,-16.26,;16.14,-17.8,;14.81,-18.57,;13.47,-17.81,;13.47,-16.26,;14.81,-15.49,;12.14,-18.58,;12.15,-20.13,;10.81,-20.9,;10.81,-22.44,;9.48,-23.21,;9.47,-24.74,;10.81,-25.52,;10.81,-27.06,;12.15,-24.74,;12.14,-23.2,;13.47,-22.43,;9.48,-20.13,;8.15,-20.91,;6.81,-20.13,;6.81,-18.59,;5.47,-17.82,;8.14,-17.82,;8.15,-16.29,;6.82,-15.52,;5.49,-16.29,;6.81,-13.98,;8.15,-13.21,;9.49,-13.98,;9.48,-15.52,;10.82,-16.29,;9.47,-18.59,;10.81,-17.82,)| Show InChI InChI=1S/C31H28Cl3FN2O3/c1-31(2,30(39)40-3)36-13-11-18(12-14-36)19-15-23(21-8-7-20(35)17-26(21)34)22-9-10-28(38)37(27(22)16-19)29-24(32)5-4-6-25(29)33/h4-10,15-18H,11-14H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.59 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of TNF alpha release in THP1 cells |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065
BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175756
(CHEMBL199632 | methyl 2-(4-(5-(2-chloro-4-fluoroph...)Show SMILES COC(=O)C(C)(C)N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(20.15,-17.01,;20.14,-15.47,;18.8,-14.71,;18.79,-13.17,;17.48,-15.49,;18.25,-16.82,;16.7,-14.16,;16.14,-16.26,;16.14,-17.8,;14.81,-18.57,;13.47,-17.81,;13.47,-16.26,;14.81,-15.49,;12.14,-18.58,;12.15,-20.13,;10.81,-20.9,;10.81,-22.44,;9.48,-23.21,;9.47,-24.74,;10.81,-25.52,;10.81,-27.06,;12.15,-24.74,;12.14,-23.2,;13.47,-22.43,;9.48,-20.13,;8.15,-20.91,;6.81,-20.13,;6.81,-18.59,;5.47,-17.82,;8.14,-17.82,;8.15,-16.29,;6.82,-15.52,;5.49,-16.29,;6.81,-13.98,;8.15,-13.21,;9.49,-13.98,;9.48,-15.52,;10.82,-16.29,;9.47,-18.59,;10.81,-17.82,)| Show InChI InChI=1S/C31H28Cl3FN2O3/c1-31(2,30(39)40-3)36-13-11-18(12-14-36)19-15-23(21-8-7-20(35)17-26(21)34)22-9-10-28(38)37(27(22)16-19)29-24(32)5-4-6-25(29)33/h4-10,15-18H,11-14H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of P38 alpha MAPK |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065
BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175756
(CHEMBL199632 | methyl 2-(4-(5-(2-chloro-4-fluoroph...)Show SMILES COC(=O)C(C)(C)N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(20.15,-17.01,;20.14,-15.47,;18.8,-14.71,;18.79,-13.17,;17.48,-15.49,;18.25,-16.82,;16.7,-14.16,;16.14,-16.26,;16.14,-17.8,;14.81,-18.57,;13.47,-17.81,;13.47,-16.26,;14.81,-15.49,;12.14,-18.58,;12.15,-20.13,;10.81,-20.9,;10.81,-22.44,;9.48,-23.21,;9.47,-24.74,;10.81,-25.52,;10.81,-27.06,;12.15,-24.74,;12.14,-23.2,;13.47,-22.43,;9.48,-20.13,;8.15,-20.91,;6.81,-20.13,;6.81,-18.59,;5.47,-17.82,;8.14,-17.82,;8.15,-16.29,;6.82,-15.52,;5.49,-16.29,;6.81,-13.98,;8.15,-13.21,;9.49,-13.98,;9.48,-15.52,;10.82,-16.29,;9.47,-18.59,;10.81,-17.82,)| Show InChI InChI=1S/C31H28Cl3FN2O3/c1-31(2,30(39)40-3)36-13-11-18(12-14-36)19-15-23(21-8-7-20(35)17-26(21)34)22-9-10-28(38)37(27(22)16-19)29-24(32)5-4-6-25(29)33/h4-10,15-18H,11-14H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of LPS stimulated TNF alpha release in whole blood |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065
BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this
Ligand-Target Pair | |
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