Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM50175759' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175759
(7-(1-tert-butylpiperidin-4-yl)-5-(2-chlorophenyl)-...)Show SMILES CC(C)(C)N1CCC(CC1)c1cc2n(-c3c(Cl)cccc3Cl)c(=O)ccc2c(n1)-c1ccccc1Cl |(34.74,5.09,;33.42,4.32,;34.19,2.98,;32.64,5.65,;32.08,3.55,;32.08,2.01,;30.75,1.24,;29.41,2,;29.41,3.54,;30.75,4.31,;28.08,1.23,;26.74,1.99,;25.41,1.22,;24.08,1.99,;24.08,3.52,;22.75,4.29,;21.42,3.52,;22.75,5.82,;24.09,6.6,;25.42,5.83,;25.42,4.29,;26.75,3.52,;22.74,1.22,;21.41,1.99,;22.74,-.32,;24.08,-1.1,;25.41,-.32,;26.75,-1.09,;28.08,-.32,;26.75,-2.63,;25.41,-3.4,;25.41,-4.94,;26.75,-5.71,;28.09,-4.93,;28.08,-3.39,;29.41,-2.62,)| Show InChI InChI=1S/C29H28Cl3N3O/c1-29(2,3)34-15-13-18(14-16-34)24-17-25-20(27(33-24)19-7-4-5-8-21(19)30)11-12-26(36)35(25)28-22(31)9-6-10-23(28)32/h4-12,17-18H,13-16H2,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibition of P38 alpha MAPK |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065 BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175759
(7-(1-tert-butylpiperidin-4-yl)-5-(2-chlorophenyl)-...)Show SMILES CC(C)(C)N1CCC(CC1)c1cc2n(-c3c(Cl)cccc3Cl)c(=O)ccc2c(n1)-c1ccccc1Cl |(34.74,5.09,;33.42,4.32,;34.19,2.98,;32.64,5.65,;32.08,3.55,;32.08,2.01,;30.75,1.24,;29.41,2,;29.41,3.54,;30.75,4.31,;28.08,1.23,;26.74,1.99,;25.41,1.22,;24.08,1.99,;24.08,3.52,;22.75,4.29,;21.42,3.52,;22.75,5.82,;24.09,6.6,;25.42,5.83,;25.42,4.29,;26.75,3.52,;22.74,1.22,;21.41,1.99,;22.74,-.32,;24.08,-1.1,;25.41,-.32,;26.75,-1.09,;28.08,-.32,;26.75,-2.63,;25.41,-3.4,;25.41,-4.94,;26.75,-5.71,;28.09,-4.93,;28.08,-3.39,;29.41,-2.62,)| Show InChI InChI=1S/C29H28Cl3N3O/c1-29(2,3)34-15-13-18(14-16-34)24-17-25-20(27(33-24)19-7-4-5-8-21(19)30)11-12-26(36)35(25)28-22(31)9-6-10-23(28)32/h4-12,17-18H,13-16H2,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibition of LPS stimulated TNF alpha release in whole blood |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065 BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this Ligand-Target Pair | |