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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM50194676'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50194676
PNG
(1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phen...)
Show SMILES CNc1ncc2cc(ccc2n1)-c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H20F3N5O/c1-14-6-8-19(31-23(33)30-18-5-3-4-17(11-18)24(25,26)27)12-20(14)15-7-9-21-16(10-15)13-29-22(28-2)32-21/h3-13H,1-2H3,(H,28,29,32)(H2,30,31,33)
PDB
MMDB

NCI pathway
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PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha by HTRF kinase assay


J Med Chem 49: 5671-86 (2006)


Article DOI: 10.1021/jm0605482
BindingDB Entry DOI: 10.7270/Q29G5MFD
More data for this
Ligand-Target Pair