Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM50375794' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50375794
(CHEMBL409901)Show SMILES Clc1ccccc1-c1cc(OCCNC(=O)[C@@H]2CCCN2)cc2n(-c3c(Cl)cccc3Cl)c(=O)ccc12 |wU:16.16,(24.63,-15.07,;23.3,-15.85,;23.3,-17.38,;21.96,-18.16,;20.63,-17.39,;20.63,-15.85,;21.97,-15.08,;21.97,-13.54,;23.3,-12.77,;23.3,-11.23,;24.63,-10.45,;25.97,-11.22,;27.3,-10.45,;28.64,-11.21,;28.61,-12.75,;27.21,-13.5,;29.93,-13.53,;30.06,-15.07,;31.52,-15.39,;32.33,-14.07,;31.33,-12.91,;21.97,-10.47,;20.64,-11.23,;19.31,-10.46,;19.31,-8.91,;17.99,-8.15,;16.66,-8.92,;17.99,-6.61,;19.32,-5.83,;20.66,-6.6,;20.66,-8.14,;21.99,-8.92,;17.98,-11.23,;16.65,-10.47,;17.98,-12.78,;19.31,-13.54,;20.64,-12.77,)| Show InChI InChI=1S/C28H24Cl3N3O3/c29-21-6-2-1-5-18(21)20-15-17(37-14-13-33-28(36)24-9-4-12-32-24)16-25-19(20)10-11-26(35)34(25)27-22(30)7-3-8-23(27)31/h1-3,5-8,10-11,15-16,24,32H,4,9,12-14H2,(H,33,36)/t24-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 2222-6 (2008)
Article DOI: 10.1016/j.bmcl.2006.10.097 BindingDB Entry DOI: 10.7270/Q23T9J36 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50375794
(CHEMBL409901)Show SMILES Clc1ccccc1-c1cc(OCCNC(=O)[C@@H]2CCCN2)cc2n(-c3c(Cl)cccc3Cl)c(=O)ccc12 |wU:16.16,(24.63,-15.07,;23.3,-15.85,;23.3,-17.38,;21.96,-18.16,;20.63,-17.39,;20.63,-15.85,;21.97,-15.08,;21.97,-13.54,;23.3,-12.77,;23.3,-11.23,;24.63,-10.45,;25.97,-11.22,;27.3,-10.45,;28.64,-11.21,;28.61,-12.75,;27.21,-13.5,;29.93,-13.53,;30.06,-15.07,;31.52,-15.39,;32.33,-14.07,;31.33,-12.91,;21.97,-10.47,;20.64,-11.23,;19.31,-10.46,;19.31,-8.91,;17.99,-8.15,;16.66,-8.92,;17.99,-6.61,;19.32,-5.83,;20.66,-6.6,;20.66,-8.14,;21.99,-8.92,;17.98,-11.23,;16.65,-10.47,;17.98,-12.78,;19.31,-13.54,;20.64,-12.77,)| Show InChI InChI=1S/C28H24Cl3N3O3/c29-21-6-2-1-5-18(21)20-15-17(37-14-13-33-28(36)24-9-4-12-32-24)16-25-19(20)10-11-26(35)34(25)27-22(30)7-3-8-23(27)31/h1-3,5-8,10-11,15-16,24,32H,4,9,12-14H2,(H,33,36)/t24-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of p38-alpha by whole blood assay |
Bioorg Med Chem Lett 18: 2222-6 (2008)
Article DOI: 10.1016/j.bmcl.2006.10.097 BindingDB Entry DOI: 10.7270/Q23T9J36 |
More data for this Ligand-Target Pair | |