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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM50418600'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50418600
PNG
(CHEMBL1784165)
Show SMILES Cc1c(Cl)cc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)NC1CC1
Show InChI InChI=1S/C22H23ClN2O2/c1-13-19(10-17(11-20(13)23)22(27)25-18-8-9-18)15-4-6-16(7-5-15)21(26)24-12-14-2-3-14/h4-7,10-11,14,18H,2-3,8-9,12H2,1H3,(H,24,26)(H,25,27)
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MMDB

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PC cid
PC sid
UniChem
Article
PubMed
12.6n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p38alpha by fluorescence polarization method


J Med Chem 52: 6257-69 (2009)


Article DOI: 10.1021/jm9004779
BindingDB Entry DOI: 10.7270/Q2J967NC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50418600
PNG
(CHEMBL1784165)
Show SMILES Cc1c(Cl)cc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)NC1CC1
Show InChI InChI=1S/C22H23ClN2O2/c1-13-19(10-17(11-20(13)23)22(27)25-18-8-9-18)15-4-6-16(7-5-15)21(26)24-12-14-2-3-14/h4-7,10-11,14,18H,2-3,8-9,12H2,1H3,(H,24,26)(H,25,27)
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PC cid
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n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of p38alpha-dependent TNFalpha production in human PBMC preincubated for 1 hr before LPS challenge by ELISA


J Med Chem 52: 6257-69 (2009)


Article DOI: 10.1021/jm9004779
BindingDB Entry DOI: 10.7270/Q2J967NC
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50418600
PNG
(CHEMBL1784165)
Show SMILES Cc1c(Cl)cc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)NC1CC1
Show InChI InChI=1S/C22H23ClN2O2/c1-13-19(10-17(11-20(13)23)22(27)25-18-8-9-18)15-4-6-16(7-5-15)21(26)24-12-14-2-3-14/h4-7,10-11,14,18H,2-3,8-9,12H2,1H3,(H,24,26)(H,25,27)
PDB
MMDB

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PC cid
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n/an/a 1.26E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISA


J Med Chem 52: 6257-69 (2009)


Article DOI: 10.1021/jm9004779
BindingDB Entry DOI: 10.7270/Q2J967NC
More data for this
Ligand-Target Pair