Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 12' and Ligand = 'BDBM365231'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365231 (US9868720, No. 65 | [2-(2-Methyl-pyrrolidin- 1-yl)...) Show SMILES CC1CCCN1c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCNCC1 Show InChI InChI=1S/C20H25F3N6/c1-13-3-2-10-29(13)19-26-16(14-4-7-24-8-5-14)12-18(28-19)27-17-11-15(6-9-25-17)20(21,22)23/h6,9,11-14,24H,2-5,7-8,10H2,1H3,(H,25,26,27,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.735	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
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