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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8' and Ligand = 'BDBM21919'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM21919
PNG
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[6...)
Show SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cccc(n4)N4CCOCC4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C26H21Cl2FN6O/c27-21-11-17(4-5-23(21)29)34-25-16(13-30)14-32-26-20(25)10-19(12-22(26)28)31-15-18-2-1-3-24(33-18)35-6-8-36-9-7-35/h1-5,10-12,14,31H,6-9,15H2,(H,32,34)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 350n/an/an/an/a7.230



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...


J Med Chem 50: 4728-45 (2007)


Article DOI: 10.1021/jm070436q
BindingDB Entry DOI: 10.7270/Q2891441
More data for this
Ligand-Target Pair