Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8' and Ligand = 'BDBM29903'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM29903 (substituted 6-aminoquinoline-3-carbonitrile, 14) Show SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(Cc5cccnc5)nn4)cc23)C#N)cc1Cl Show InChI InChI=1S/C25H17Cl2FN8/c26-21-7-17(3-4-23(21)28)33-24-16(9-29)11-32-25-20(24)6-18(8-22(25)27)31-12-19-14-36(35-34-19)13-15-2-1-5-30-10-15/h1-8,10-11,14,31H,12-13H2,(H,32,33)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.2	30
Wyeth Research					Assay Description Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...				Bioorg Med Chem Lett 19: 3485-8 (2009) Article DOI: 10.1016/j.bmcl.2009.05.009 BindingDB Entry DOI: 10.7270/Q2HT2MN8
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