Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8' and Ligand = 'BDBM50173841'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50173841 (4-(4-chloro-2-fluorophenylamino)-6-(2-morpholinoet...) Show SMILES Fc1cc(Cl)ccc1Nc1c(cnc2cnc(NCCN3CCOCC3)cc12)C#N Show InChI InChI=1S/C21H20ClFN6O/c22-15-1-2-18(17(23)9-15)28-21-14(11-24)12-26-19-13-27-20(10-16(19)21)25-3-4-29-5-7-30-8-6-29/h1-2,9-10,12-13H,3-8H2,(H,25,27)(H,26,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation				Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M
					More data for this Ligand-Target Pair