Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8' and Ligand = 'BDBM50173844'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50173844 (4-(3-chloro-4-fluorophenylamino)-6-(2-morpholino-1...) Show SMILES Fc1ccc(Nc2c(cnc3cnc(NC(CN4CCOCC4)c4ccccc4)cc23)C#N)cc1Cl Show InChI InChI=1S/C27H24ClFN6O/c28-22-12-20(6-7-23(22)29)33-27-19(14-30)15-31-24-16-32-26(13-21(24)27)34-25(18-4-2-1-3-5-18)17-35-8-10-36-11-9-35/h1-7,12-13,15-16,25H,8-11,17H2,(H,31,33)(H,32,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylation				Bioorg Med Chem Lett 15: 5288-92 (2005) Article DOI: 10.1016/j.bmcl.2005.08.029 BindingDB Entry DOI: 10.7270/Q2JS9Q0M
					More data for this Ligand-Target Pair