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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8' and Ligand = 'BDBM50194985'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194985
PNG
(CHEMBL374852 | N-(4-(3-chloro-4-fluorophenylamino)...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NS(=O)(=O)c4ccccc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H14ClFN4O2S/c23-19-11-15(6-8-20(19)24)27-22-14(12-25)13-26-21-9-7-16(10-18(21)22)28-31(29,30)17-4-2-1-3-5-17/h1-11,13,28H,(H,26,27)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.15E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair