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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8' and Ligand = 'BDBM50194990'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194990
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(2-morpholinoet...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCCN4CCOCC4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H21ClFN5O/c23-19-12-17(1-3-20(19)24)28-22-15(13-25)14-27-21-4-2-16(11-18(21)22)26-5-6-29-7-9-30-10-8-29/h1-4,11-12,14,26H,5-10H2,(H,27,28)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair