Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 4' and Ligand = 'BDBM299489'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299489 (N-[3-(4-amino- quinazolin-6-yl) phenyl]-2-(2- oxop...) Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(NC(=O)CN2CCCC2=O)c1 Show InChI InChI=1S/C20H19N5O2/c21-20-16-10-14(6-7-17(16)22-12-23-20)13-3-1-4-15(9-13)24-18(26)11-25-8-2-5-19(25)27/h1,3-4,6-7,9-10,12H,2,5,8,11H2,(H,24,26)(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	328	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299489 (N-[3-(4-amino- quinazolin-6-yl) phenyl]-2-(2- oxop...) Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(NC(=O)CN2CCCC2=O)c1 Show InChI InChI=1S/C20H19N5O2/c21-20-16-10-14(6-7-17(16)22-12-23-20)13-3-1-4-15(9-13)24-18(26)11-25-8-2-5-19(25)27/h1,3-4,6-7,9-10,12H,2,5,8,11H2,(H,24,26)(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	328	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair