Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 4' and Ligand = 'BDBM299523'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299523 (6-[3-(2-pyridyl)-1- piperidyl]pyrido [3,2-d]pyrimi...) Show SMILES Nc1ncnc2ccc(nc12)N1CCCC(C1)c1ccccn1 Show InChI InChI=1S/C17H18N6/c18-17-16-14(20-11-21-17)6-7-15(22-16)23-9-3-4-12(10-23)13-5-1-2-8-19-13/h1-2,5-8,11-12H,3-4,9-10H2,(H2,18,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	76.4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299523 (6-[3-(2-pyridyl)-1- piperidyl]pyrido [3,2-d]pyrimi...) Show SMILES Nc1ncnc2ccc(nc12)N1CCCC(C1)c1ccccn1 Show InChI InChI=1S/C17H18N6/c18-17-16-14(20-11-21-17)6-7-15(22-16)23-9-3-4-12(10-23)13-5-1-2-8-19-13/h1-2,5-8,11-12H,3-4,9-10H2,(H2,18,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	76.4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair