Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 4' and Ligand = 'BDBM299545'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299545 (N-[6-(3-amino-5- fluoro-phenyl) pyrido[3,2-d] pyri...) Show SMILES Nc1cc(F)cc(c1)-c1ccc2ncnc(NC(=O)CN3CCCC3)c2n1 Show InChI InChI=1S/C19H19FN6O/c20-13-7-12(8-14(21)9-13)15-3-4-16-18(24-15)19(23-11-22-16)25-17(27)10-26-5-1-2-6-26/h3-4,7-9,11H,1-2,5-6,10,21H2,(H,22,23,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	232	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299545 (N-[6-(3-amino-5- fluoro-phenyl) pyrido[3,2-d] pyri...) Show SMILES Nc1cc(F)cc(c1)-c1ccc2ncnc(NC(=O)CN3CCCC3)c2n1 Show InChI InChI=1S/C19H19FN6O/c20-13-7-12(8-14(21)9-13)15-3-4-16-18(24-15)19(23-11-22-16)25-17(27)10-26-5-1-2-6-26/h3-4,7-9,11H,1-2,5-6,10,21H2,(H,22,23,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	232	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair