Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human)) | BDBM50011564 (CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB D3R | 108 | n/a | 92.7 | n/a | n/a | n/a | n/a | n/a | n/a |
D3R | Assay Description Z'Lyte Assay | D3R 409: (2016) BindingDB Entry DOI: 10.7270/Q2R49PN1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human)) | BDBM50011564 (CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Inhibition of human MAP4K4 using 5-FAM-LGRDKYKTLRQIRQ-COOH as substrate by Z'-LYTE assay | J Med Chem 57: 3484-93 (2014) Article DOI: 10.1021/jm500155b BindingDB Entry DOI: 10.7270/Q2M046ZR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human)) | BDBM50011564 (CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 92.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. US Patent | Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ... | US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human)) | BDBM50011564 (CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 92.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research | Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ... | J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |