BindingDB PrimarySearch

Found 28 hits Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M2' and Ligand = 'BDBM50064176'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]AF-DX384 from muscarinic M2 receptor				J Nat Prod 56: 441-455 (1993) Article DOI: 10.1021/np50094a001 BindingDB Entry DOI: 10.7270/Q2VT1S4B
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	3.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by PDSP K_i Database									Mol Pharmacol 35: 469-76 (1989) BindingDB Entry DOI: 10.7270/Q2V69H2Z
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	4.57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Group Research Ltd. Curated by PDSP K_i Database									Mol Pharmacol 38: 805-15 (1990) BindingDB Entry DOI: 10.7270/Q2H993P0
Glaxo Group Research Ltd. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute for Medical Research Curated by PDSP K_i Database									Annu Rev Pharmacol Toxicol 30: 633-73 (1990) Article DOI: 10.1146/annurev.pa.30.040190.003221 BindingDB Entry DOI: 10.7270/Q21Z42WK
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	13.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Neurological Disorders and Stroke Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 727-33 (1991) BindingDB Entry DOI: 10.7270/Q2VD6WZ3
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates				Citation and Details BindingDB Entry DOI: 10.7270/Q2ZK5JTF
TBA					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	14.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells				J Med Chem 44: 4035-8 (2001) BindingDB Entry DOI: 10.7270/Q21R6PTT
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	14.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pisa Curated by PDSP K_i Database									Eur J Pharmacol 268: 459-62 (1994) Article DOI: 10.1016/0922-4106(94)90075-2 BindingDB Entry DOI: 10.7270/Q2348HWT
University of Pisa Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	14.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by PDSP K_i Database									J Med Chem 36: 3734-7 (1993) Article DOI: 10.1021/jm00075a032 BindingDB Entry DOI: 10.7270/Q2W957Q0
University of Bologna Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Camerino Curated by ChEMBL					Assay Description Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-NMS from rat heart				J Med Chem 41: 1557-60 (1998) Article DOI: 10.1021/jm970740r BindingDB Entry DOI: 10.7270/Q2N29W3Q
University of Camerino Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	16.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									J Pharmacol Exp Ther 250: 565-72 (1989) BindingDB Entry DOI: 10.7270/Q2GX492D
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Libre de Bruxelles Curated by PDSP K_i Database									Mol Pharmacol 38: 267-73 (1990) BindingDB Entry DOI: 10.7270/Q2NP22X3
Université Libre de Bruxelles Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2				J Med Chem 41: 4150-60 (1998) Checked by Author Article DOI: 10.1021/jm981038d BindingDB Entry DOI: 10.7270/Q2KH0PJH
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Adamed Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells				J Med Chem 57: 4543-57 (2014) Article DOI: 10.1021/jm401895u BindingDB Entry DOI: 10.7270/Q2N29ZHX
Adamed Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by PDSP K_i Database									J Pharmacol Exp Ther 284: 500-7 (1998) BindingDB Entry DOI: 10.7270/Q2HX1B6S
University of Arizona Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by PDSP K_i Database									Life Sci 47: 1001-13 (1990) Article DOI: 10.1016/0024-3205(90)90472-4 BindingDB Entry DOI: 10.7270/Q2F47MM6
University of Arizona Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	49	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by PDSP K_i Database									J Pharmacol Exp Ther 284: 500-7 (1998) BindingDB Entry DOI: 10.7270/Q2HX1B6S
University of Arizona Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	77.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit&aagrove; di Milano Curated by PDSP K_i Database									Farmaco 58: 739-48 (2003) Article DOI: 10.1016/S0014-827X(03)00113-7 BindingDB Entry DOI: 10.7270/Q21G0JVK
Universit&aagrove; di Milano Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	88	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by PDSP K_i Database									Mol Pharmacol 35: 469-76 (1989) BindingDB Entry DOI: 10.7270/Q2V69H2Z
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	424	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1173-81 (1991) BindingDB Entry DOI: 10.7270/Q2BC3X18
University of California Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	638	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1173-81 (1991) BindingDB Entry DOI: 10.7270/Q2BC3X18
University of California Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	653	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1173-81 (1991) BindingDB Entry DOI: 10.7270/Q2BC3X18
University of California Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	833	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1173-81 (1991) BindingDB Entry DOI: 10.7270/Q2BC3X18
University of California Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells				Bioorg Med Chem 24: 1793-810 (2016) Article DOI: 10.1016/j.bmc.2016.03.006 BindingDB Entry DOI: 10.7270/Q2J67JS7
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method				Bioorg Med Chem 25: 471-482 (2017) Article DOI: 10.1016/j.bmc.2016.11.014 BindingDB Entry DOI: 10.7270/Q2CF9S3S
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Urbino Carlo Bo Curated by ChEMBL					Assay Description Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA				J Med Chem 48: 6887-96 (2005) Article DOI: 10.1021/jm058018d BindingDB Entry DOI: 10.7270/Q28C9X1X
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human muscarinic M2 receptor				Bioorg Med Chem 18: 7675-99 (2010) Article DOI: 10.1016/j.bmc.2010.07.034 BindingDB Entry DOI: 10.7270/Q2DF6S69
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (GUINEA PIG)	BDBM50064176 (CHEMBL27673 \| CHEMBL500996 \| METHOCTRAMINE \| N,N''...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
University of Wuerzburg Curated by ChEMBL					Assay Description Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart				J Med Chem 46: 1390-407 (2003) Article DOI: 10.1021/jm021077w BindingDB Entry DOI: 10.7270/Q2JD50JS
University of Wuerzburg Curated by ChEMBL					More data for this Ligand-Target Pair