Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent histone deacetylase SIR2 (Saccharomyces cerevisiae) | BDBM27507 (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Guru Jambheshwar University of Science and Technology Curated by ChEMBL | Assay Description Non-competitive inhibition of recombinant yeast glutathione-S-transferase-tagged SIRT2 using acetylated histone as substrate measured after 30 mins b... | Eur J Med Chem 119: 45-69 (2016) Article DOI: 10.1016/j.ejmech.2016.04.063 BindingDB Entry DOI: 10.7270/Q2VH5QTW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |