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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'NAD-dependent histone deacetylase SIR2' and Ligand = 'BDBM50146061'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NAD-dependent histone deacetylase SIR2


(Saccharomyces cerevisiae)		BDBM50146061
PNG
(CHEMBL89585 | {2-[2-(3-Oxo-2,3-dihydro-1H-benzo[f]...)
Show SMILES CC(C)(C)OC(=O)NCCOCCOc1cc2ccccc2c2CCC(=O)Oc12
Show InChI InChI=1S/C22H27NO6/c1-22(2,3)29-21(25)23-10-11-26-12-13-27-18-14-15-6-4-5-7-16(15)17-8-9-19(24)28-20(17)18/h4-7,14H,8-13H2,1-3H3,(H,23,25)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.60E+4n/an/an/an/an/an/a



Fred Hutchinson Cancer Research Center

Curated by ChEMBL


Assay Description
In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates

J Med Chem 47: 2635-44 (2004)


Article DOI: 10.1021/jm030473r
BindingDB Entry DOI: 10.7270/Q228071B
More data for this
Ligand-Target Pair