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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'NADPH oxidase 4' and Ligand = 'BDBM50330716'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50330716
PNG
(2-(2-chlorophenyl)-5-(2-(dimethylamino)ethyl)-4-me...)
Show SMILES CN(C)CCn1c(C)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O
Show InChI InChI=1S/C17H19ClN4O2/c1-11-16-13(10-15(23)21(11)9-8-20(2)3)19-22(17(16)24)14-7-5-4-6-12(14)18/h4-7,10,19H,8-9H2,1-3H3
KEGG

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PC cid
PC sid
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Patents

Similars
Article
PubMed
 235n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH

J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair