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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'NADPH oxidase 4' and Ligand = 'BDBM50330719'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50330719
PNG
(CHEMBL1276857 | N-(2-(2-chlorophenyl)-4-methyl-3,6...)
Show SMILES Cc1n(NC(=O)COc2ccc(F)cc2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C21H16ClFN4O4/c1-12-20-16(24-27(21(20)30)17-5-3-2-4-15(17)22)10-19(29)26(12)25-18(28)11-31-14-8-6-13(23)7-9-14/h2-10,24H,11H2,1H3,(H,25,28)
KEGG

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PC cid
PC sid
UniChem

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Article
PubMed
 218n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH

J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair