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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'NF-kappa-beta-inducing kinase (NF-kB)' and Ligand = 'BDBM158904'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158904
PNG
(US9034866, 379)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3c(Cc4ccnn4C)c(nc3-c2c1)C(N)=O |r,wU:6.7,wD:6.8,(2.74,4.12,;4.07,3.35,;4.55,1.89,;6.09,1.89,;6.56,3.35,;5.32,4.26,;6.86,.55,;7.63,1.89,;8.19,-.22,;5.52,-.22,;4.19,-.99,;2.86,-1.76,;2.86,-3.3,;1.52,-4.07,;.19,-3.3,;-1.01,-4.26,;-2.52,-3.91,;-3.18,-2.53,;-1.57,-2.53,;-2.52,-1.14,;-3.31,.18,;-4.79,.58,;-5.88,-.51,;-5.41,-1.97,;-6.65,-2.88,;-7.9,-1.97,;-7.42,-.51,;-8.19,.83,;-2.29,1.34,;-.88,.74,;-1.01,-.8,;.19,-1.76,;1.52,-.99,;-2.69,2.83,;-4.18,3.23,;-1.6,3.92,)|
Show InChI InChI=1/C27H26N6O3/c1-15-10-23(31-36-15)27(2,35)8-6-16-4-5-20-17-12-19(13-17)33-22(14-18-7-9-29-32(18)3)24(25(28)34)30-26(33)21(20)11-16/h4-5,7,9-11,17,19,35H,12-14H2,1-3H3,(H2,28,34)/t17?,19?,27-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
0.200n/an/an/an/an/an/a7.2n/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)


BindingDB Entry DOI: 10.7270/Q2GX49B0
More data for this
Ligand-Target Pair