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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Neprilysin' and Ligand = 'BDBM299635'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM299635
PNG
((2R,4R)-5-(5′-Chloro-2′-fluorobiphenyl...)
Show SMILES CCc1cc(on1)C(=O)N[C@@H](C[C@@H](CNC(=O)OC)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F |r|
Show InChI InChI=1S/C26H27ClFN3O6/c1-3-19-13-23(37-31-19)24(32)30-20(11-17(25(33)34)14-29-26(35)36-2)10-15-4-6-16(7-5-15)21-12-18(27)8-9-22(21)28/h4-9,12-13,17,20H,3,10-11,14H2,1-2H3,(H,29,35)(H,30,32)(H,33,34)/t17-,20+/m0/s1
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair