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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Neprilysin' and Ligand = 'BDBM300272'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300272
PNG
(US9593110, 62)
Show SMILES OC(=O)[C@@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)Cn1ccnc1
Show InChI InChI=1S/C24H22ClFN6O3/c25-18-5-6-21(26)20(11-18)16-3-1-15(2-4-16)9-19(29-23(33)22-12-28-31-30-22)10-17(24(34)35)13-32-8-7-27-14-32/h1-8,11-12,14,17,19H,9-10,13H2,(H,29,33)(H,34,35)(H,28,30,31)/t17-,19+/m0/s1
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair