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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Neprilysin' and Ligand = 'BDBM300284'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300284
PNG
(US9593110, 4-1)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1n[nH]c(n1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C23H22ClF3N4O4/c1-35-12-16(21(33)34)11-18(28-20(32)19-29-22(31-30-19)23(25,26)27)9-13-5-7-14(8-6-13)15-3-2-4-17(24)10-15/h2-8,10,16,18H,9,11-12H2,1H3,(H,28,32)(H,33,34)(H,29,30,31)/t16-,18+/m0/s1
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair