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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Neprilysin' and Ligand = 'BDBM300314'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300314
PNG
(US9593110, 9-5)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1noc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C23H24ClN3O6/c1-2-32-13-17(22(29)30)12-19(25-21(28)20-26-23(31)33-27-20)10-14-6-8-15(9-7-14)16-4-3-5-18(24)11-16/h3-9,11,17,19H,2,10,12-13H2,1H3,(H,25,28)(H,29,30)(H,26,27,31)/t17-,19+/m0/s1
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair