Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Neprilysin (Rattus norvegicus (Rat)) | BDBM50024096 (((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of neutral endopeptidase(NEP). | Bioorg Med Chem Lett 6: 2053-2058 (1996) Article DOI: 10.1016/0960-894X(96)00367-8 BindingDB Entry DOI: 10.7270/Q29G5MSW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM50024096 (((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibition of recombinant human neprilysin(NEP). | Bioorg Med Chem Lett 6: 2437-2440 (1996) Article DOI: 10.1016/0960-894X(96)00448-9 BindingDB Entry DOI: 10.7270/Q2JS9QD0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Rattus norvegicus (Rat)) | BDBM50024096 (((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Marion Merrell Dow Research Institute Curated by ChEMBL | Assay Description Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determined | J Med Chem 36: 2420-3 (1993) BindingDB Entry DOI: 10.7270/Q22N51C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Rattus norvegicus (Rat)) | BDBM50024096 (((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for inhibition of rat kidney neutral endopeptidase | Bioorg Med Chem Lett 6: 2097-2102 (1996) Article DOI: 10.1016/0960-894X(96)00375-7 BindingDB Entry DOI: 10.7270/Q2X92B8K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Rattus norvegicus (Rat)) | BDBM50024096 (((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration for 50% inhibition of activity of rat kidney enkephalinase | J Med Chem 29: 751-7 (1986) BindingDB Entry DOI: 10.7270/Q2HM57F3 | |||||||||||
More data for this Ligand-Target Pair |