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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Neprilysin' and Ligand = 'BDBM50190738'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM50190738
PNG
(2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cy...)
Show SMILES CCc1nnc(NC(=O)C2(CC(CCC(C)C)C(O)=O)CCCC2)s1
Show InChI InChI=1S/C18H29N3O3S/c1-4-14-20-21-17(25-14)19-16(24)18(9-5-6-10-18)11-13(15(22)23)8-7-12(2)3/h12-13H,4-11H2,1-3H3,(H,22,23)(H,19,21,24)
PDB

KEGG

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dog NEP

J Med Chem 49: 4409-24 (2006)


Article DOI: 10.1021/jm060133g
BindingDB Entry DOI: 10.7270/Q2930SS8
More data for this
Ligand-Target Pair