Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS/IPBS (Institut de Pharmacologie et Biologie Structurale) Curated by ChEMBL | Assay Description Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M... | J Med Chem 58: 8834-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00925 BindingDB Entry DOI: 10.7270/Q2RN3BVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells | Bioorg Med Chem 18: 6292-304 (2010) Article DOI: 10.1016/j.bmc.2010.07.028 BindingDB Entry DOI: 10.7270/Q2416X87 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells | Bioorg Med Chem 21: 6303-22 (2013) Article DOI: 10.1016/j.bmc.2013.08.065 BindingDB Entry DOI: 10.7270/Q2J104MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells | Bioorg Med Chem 19: 2859-78 (2011) Article DOI: 10.1016/j.bmc.2011.03.045 BindingDB Entry DOI: 10.7270/Q2F47PG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Regensburg Curated by ChEMBL | Assay Description Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells | Bioorg Med Chem 16: 9858-66 (2008) Article DOI: 10.1016/j.bmc.2008.09.033 BindingDB Entry DOI: 10.7270/Q2KW5FWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells | J Med Chem 51: 8168-72 (2008) Article DOI: 10.1021/jm801018u BindingDB Entry DOI: 10.7270/Q2WM1D8T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS/IPBS (Institut de Pharmacologie et Biologie Structurale) Curated by ChEMBL | Assay Description Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay | J Med Chem 58: 8834-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00925 BindingDB Entry DOI: 10.7270/Q2RN3BVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS/IPBS (Institut de Pharmacologie et Biologie Structurale) Curated by ChEMBL | Assay Description Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis | J Med Chem 58: 8834-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00925 BindingDB Entry DOI: 10.7270/Q2RN3BVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells | J Med Chem 51: 8168-72 (2008) Article DOI: 10.1021/jm801018u BindingDB Entry DOI: 10.7270/Q2WM1D8T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Regensburg Curated by ChEMBL | Assay Description Displacement of radiolabled NPY from human Y1R expressed in human SK-N-MC cells | Bioorg Med Chem 19: 2859-78 (2011) Article DOI: 10.1016/j.bmc.2011.03.045 BindingDB Entry DOI: 10.7270/Q2F47PG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane | Bioorg Med Chem Lett 12: 379-82 (2002) BindingDB Entry DOI: 10.7270/Q2DJ5DZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells | J Med Chem 40: 3712-4 (1997) Article DOI: 10.1021/jm970512x BindingDB Entry DOI: 10.7270/Q2HQ3Z1P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS/IPBS (Institut de Pharmacologie et Biologie Structurale) Curated by ChEMBL | Assay Description Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M... | J Med Chem 58: 8834-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00925 BindingDB Entry DOI: 10.7270/Q2RN3BVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Mississippi Curated by ChEMBL | Assay Description Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting | J Nat Prod 72: 2172-6 (2009) Article DOI: 10.1021/np900287e BindingDB Entry DOI: 10.7270/Q2MC910T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS/IPBS (Institut de Pharmacologie et Biologie Structurale) Curated by ChEMBL | Assay Description Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas... | J Med Chem 58: 8834-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00925 BindingDB Entry DOI: 10.7270/Q2RN3BVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS/IPBS (Institut de Pharmacologie et Biologie Structurale) Curated by ChEMBL | Assay Description Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye bas... | J Med Chem 58: 8834-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00925 BindingDB Entry DOI: 10.7270/Q2RN3BVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS/IPBS (Institut de Pharmacologie et Biologie Structurale) Curated by ChEMBL | Assay Description Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye base... | J Med Chem 58: 8834-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00925 BindingDB Entry DOI: 10.7270/Q2RN3BVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50060728 ((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a |
CNRS/IPBS (Institut de Pharmacologie et Biologie Structurale) Curated by ChEMBL | Assay Description Binding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assay | J Med Chem 58: 8834-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00925 BindingDB Entry DOI: 10.7270/Q2RN3BVG | |||||||||||
More data for this Ligand-Target Pair |