Found 2 hits Enz. Inhib. hit(s) with Target = 'Neuropeptide Y receptor type 2' and Ligand = 'BDBM50197013' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50197013
(AcPYY(25-36) | CHEMBL392889)Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:68.69,69.72,4.4,86.87,20.28,53.54,106.107,wD:61.62,8.17,30.39,75.76,45.46,95.96,(7.95,-35.96,;7.95,-37.5,;9.29,-38.27,;6.63,-38.27,;6.63,-39.81,;5.28,-40.57,;3.95,-39.8,;3.95,-38.26,;2.62,-40.57,;2.62,-42.11,;3.95,-42.88,;5.29,-42.11,;6.62,-42.88,;6.62,-44.42,;7.94,-45.18,;5.29,-45.19,;3.95,-44.42,;1.29,-39.8,;-.04,-40.59,;-.04,-42.13,;-1.37,-39.82,;-1.37,-38.28,;-.04,-37.51,;1.37,-38.14,;2.4,-36.99,;1.63,-35.66,;.12,-35.97,;-2.71,-40.58,;-4.04,-39.81,;-4.04,-38.27,;-5.37,-40.58,;-5.37,-42.12,;-4.04,-42.89,;-4.04,-44.43,;-2.71,-45.2,;-2.7,-46.74,;-4.05,-47.5,;-1.38,-47.5,;-6.71,-39.81,;-8.03,-40.6,;-9.36,-39.83,;-8.03,-42.14,;7.95,-40.58,;7.95,-42.12,;9.28,-39.8,;10.62,-40.57,;10.62,-42.11,;11.94,-42.88,;13.27,-42.11,;11.94,-44.42,;11.94,-39.8,;11.94,-38.26,;13.28,-40.57,;14.62,-39.81,;14.62,-38.27,;15.95,-37.5,;15.95,-35.96,;17.28,-38.27,;15.95,-40.58,;15.95,-42.12,;17.28,-39.8,;18.61,-40.57,;18.61,-42.11,;19.94,-42.88,;17.27,-42.88,;19.94,-39.8,;19.94,-38.26,;21.27,-40.57,;22.61,-39.8,;22.61,-38.26,;21.27,-37.49,;23.93,-37.49,;23.94,-40.57,;23.94,-42.11,;25.27,-39.8,;26.6,-40.57,;26.6,-42.11,;27.93,-42.88,;27.93,-44.42,;29.26,-45.18,;29.26,-46.72,;27.93,-47.49,;30.6,-47.49,;27.93,-39.8,;27.93,-38.26,;29.26,-40.56,;30.6,-39.8,;30.6,-38.26,;31.93,-37.49,;31.93,-35.95,;30.6,-35.18,;33.27,-35.18,;31.93,-40.57,;31.93,-42.11,;33.26,-39.8,;34.59,-40.57,;34.59,-42.11,;35.92,-42.88,;35.92,-44.42,;37.26,-45.18,;37.26,-46.72,;35.92,-47.49,;38.59,-47.49,;35.92,-39.8,;35.92,-38.26,;37.26,-40.57,;38.59,-39.8,;38.59,-38.26,;39.92,-37.49,;41.26,-38.26,;42.6,-37.49,;42.6,-35.95,;43.92,-35.18,;41.26,-35.18,;39.92,-35.95,;39.92,-40.57,;41.26,-39.8,;39.92,-42.11,)| Show InChI InChI=1S/C74H118N26O18/c1-36(2)28-51(94-66(113)53(31-42-17-21-45(104)22-18-42)96-67(114)54(32-43-34-84-35-88-43)97-61(108)46(89-40(8)102)12-9-25-85-72(78)79)65(112)98-55(33-57(76)106)68(115)95-52(29-37(3)4)69(116)99-58(38(5)6)70(117)100-59(39(7)101)71(118)92-48(14-11-27-87-74(82)83)62(109)91-49(23-24-56(75)105)64(111)90-47(13-10-26-86-73(80)81)63(110)93-50(60(77)107)30-41-15-19-44(103)20-16-41/h15-22,34-39,46-55,58-59,101,103-104H,9-14,23-33H2,1-8H3,(H2,75,105)(H2,76,106)(H2,77,107)(H,84,88)(H,89,102)(H,90,111)(H,91,109)(H,92,118)(H,93,110)(H,94,113)(H,95,115)(H,96,114)(H,97,108)(H,98,112)(H,99,116)(H,100,117)(H4,78,79,85)(H4,80,81,86)(H4,82,83,87)/t39-,46+,47+,48+,49+,50+,51+,52+,53+,54+,55+,58+,59+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharmaceuticals Corporation
Curated by ChEMBL
| Assay Description
Displacement of human [125I]PYY from NPY2 receptor expressed in human KAN-TS cells |
Bioorg Med Chem Lett 17: 538-41 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.007
BindingDB Entry DOI: 10.7270/Q2959H6F |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50197013
(AcPYY(25-36) | CHEMBL392889)Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:68.69,69.72,4.4,86.87,20.28,53.54,106.107,wD:61.62,8.17,30.39,75.76,45.46,95.96,(7.95,-35.96,;7.95,-37.5,;9.29,-38.27,;6.63,-38.27,;6.63,-39.81,;5.28,-40.57,;3.95,-39.8,;3.95,-38.26,;2.62,-40.57,;2.62,-42.11,;3.95,-42.88,;5.29,-42.11,;6.62,-42.88,;6.62,-44.42,;7.94,-45.18,;5.29,-45.19,;3.95,-44.42,;1.29,-39.8,;-.04,-40.59,;-.04,-42.13,;-1.37,-39.82,;-1.37,-38.28,;-.04,-37.51,;1.37,-38.14,;2.4,-36.99,;1.63,-35.66,;.12,-35.97,;-2.71,-40.58,;-4.04,-39.81,;-4.04,-38.27,;-5.37,-40.58,;-5.37,-42.12,;-4.04,-42.89,;-4.04,-44.43,;-2.71,-45.2,;-2.7,-46.74,;-4.05,-47.5,;-1.38,-47.5,;-6.71,-39.81,;-8.03,-40.6,;-9.36,-39.83,;-8.03,-42.14,;7.95,-40.58,;7.95,-42.12,;9.28,-39.8,;10.62,-40.57,;10.62,-42.11,;11.94,-42.88,;13.27,-42.11,;11.94,-44.42,;11.94,-39.8,;11.94,-38.26,;13.28,-40.57,;14.62,-39.81,;14.62,-38.27,;15.95,-37.5,;15.95,-35.96,;17.28,-38.27,;15.95,-40.58,;15.95,-42.12,;17.28,-39.8,;18.61,-40.57,;18.61,-42.11,;19.94,-42.88,;17.27,-42.88,;19.94,-39.8,;19.94,-38.26,;21.27,-40.57,;22.61,-39.8,;22.61,-38.26,;21.27,-37.49,;23.93,-37.49,;23.94,-40.57,;23.94,-42.11,;25.27,-39.8,;26.6,-40.57,;26.6,-42.11,;27.93,-42.88,;27.93,-44.42,;29.26,-45.18,;29.26,-46.72,;27.93,-47.49,;30.6,-47.49,;27.93,-39.8,;27.93,-38.26,;29.26,-40.56,;30.6,-39.8,;30.6,-38.26,;31.93,-37.49,;31.93,-35.95,;30.6,-35.18,;33.27,-35.18,;31.93,-40.57,;31.93,-42.11,;33.26,-39.8,;34.59,-40.57,;34.59,-42.11,;35.92,-42.88,;35.92,-44.42,;37.26,-45.18,;37.26,-46.72,;35.92,-47.49,;38.59,-47.49,;35.92,-39.8,;35.92,-38.26,;37.26,-40.57,;38.59,-39.8,;38.59,-38.26,;39.92,-37.49,;41.26,-38.26,;42.6,-37.49,;42.6,-35.95,;43.92,-35.18,;41.26,-35.18,;39.92,-35.95,;39.92,-40.57,;41.26,-39.8,;39.92,-42.11,)| Show InChI InChI=1S/C74H118N26O18/c1-36(2)28-51(94-66(113)53(31-42-17-21-45(104)22-18-42)96-67(114)54(32-43-34-84-35-88-43)97-61(108)46(89-40(8)102)12-9-25-85-72(78)79)65(112)98-55(33-57(76)106)68(115)95-52(29-37(3)4)69(116)99-58(38(5)6)70(117)100-59(39(7)101)71(118)92-48(14-11-27-87-74(82)83)62(109)91-49(23-24-56(75)105)64(111)90-47(13-10-26-86-73(80)81)63(110)93-50(60(77)107)30-41-15-19-44(103)20-16-41/h15-22,34-39,46-55,58-59,101,103-104H,9-14,23-33H2,1-8H3,(H2,75,105)(H2,76,106)(H2,77,107)(H,84,88)(H,89,102)(H,90,111)(H,91,109)(H,92,118)(H,93,110)(H,94,113)(H,95,115)(H,96,114)(H,97,108)(H,98,112)(H,99,116)(H,100,117)(H4,78,79,85)(H4,80,81,86)(H4,82,83,87)/t39-,46+,47+,48+,49+,50+,51+,52+,53+,54+,55+,58+,59+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Bayer Pharmaceuticals Corporation
Curated by ChEMBL
| Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay |
Bioorg Med Chem Lett 17: 538-41 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.007
BindingDB Entry DOI: 10.7270/Q2959H6F |
More data for this
Ligand-Target Pair | |
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