Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibition of mouse recombinant iNOS | J Med Chem 53: 7804-24 (2010) Article DOI: 10.1021/jm100947x BindingDB Entry DOI: 10.7270/Q2NC61FT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 670 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme. | J Med Chem 41: 2858-71 (1998) Article DOI: 10.1021/jm980072p BindingDB Entry DOI: 10.7270/Q2862H4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 4.28E+3 | -31.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
Northwestern University | Assay Description Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401... | J Med Chem 50: 2089-99 (2007) Article DOI: 10.1021/jm061305c BindingDB Entry DOI: 10.7270/Q2W0947W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle Research and Development Curated by ChEMBL | Assay Description Tested for inhibition of mouse inducible nitric oxide synthase | J Med Chem 37: 3886-8 (1994) BindingDB Entry DOI: 10.7270/Q29P328V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering AG Curated by ChEMBL | Assay Description In vitro inhibition of inducible nitric oxide synthase. | Bioorg Med Chem Lett 12: 2561-4 (2002) BindingDB Entry DOI: 10.7270/Q2VD6XS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering AG Curated by ChEMBL | Assay Description Inhibitory concentration against human Inducible nitric oxide synthase | Bioorg Med Chem Lett 13: 1981-4 (2003) BindingDB Entry DOI: 10.7270/Q2FN16QG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS) | J Med Chem 41: 3675-83 (1998) Article DOI: 10.1021/jm970840x BindingDB Entry DOI: 10.7270/Q2XP75MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested in vitro for inhibitory activity against inducible nitric oxide synthase | Bioorg Med Chem Lett 6: 999-1002 (1996) Article DOI: 10.1016/0960-894X(96)00144-8 BindingDB Entry DOI: 10.7270/Q2TT4QZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells | J Med Chem 41: 2636-42 (1998) Article DOI: 10.1021/jm980073h BindingDB Entry DOI: 10.7270/Q26Q1WD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.47E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of inducible NOS mediated nitric oxide production in LPS-activated Kunming mouse macrophages | Bioorg Med Chem 16: 578-85 (2008) Article DOI: 10.1016/j.bmc.2007.04.030 BindingDB Entry DOI: 10.7270/Q2P55PCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Rattus norvegicus) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle Research and Development Curated by ChEMBL | Assay Description Tested for inhibition of rat brain inducible nitric oxide synthase | J Med Chem 37: 3886-8 (1994) BindingDB Entry DOI: 10.7270/Q29P328V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.76E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of iNOS in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide overproduction incubated for 24 hrs by Griess assay | Citation and Details Article DOI: 10.1016/j.bmc.2020.115733 BindingDB Entry DOI: 10.7270/Q2VH5SFS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of inducible nitric oxide synthase (iNOS) in mice | Bioorg Med Chem Lett 14: 313-6 (2003) BindingDB Entry DOI: 10.7270/Q2XP74C4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.44E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaohsiung Medical University Curated by ChEMBL | Assay Description Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method | J Nat Prod 74: 2489-96 (2011) Article DOI: 10.1021/np100874f BindingDB Entry DOI: 10.7270/Q2ST7Q8Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Mus musculus (mouse)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.52E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaohsiung Medical University Curated by ChEMBL | Assay Description Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide product... | J Nat Prod 74: 1875-80 (2011) Article DOI: 10.1021/np200279r BindingDB Entry DOI: 10.7270/Q2474B72 | |||||||||||
More data for this Ligand-Target Pair |