Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nociceptin receptor (Homo sapiens (Human)) | BDBM21844 (8-[(1R,3aR)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.390 | -53.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Istituto Superiore di Sanita | Assay Description IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f... | J Med Chem 51: 1058-62 (2008) Article DOI: 10.1021/jm7009606 BindingDB Entry DOI: 10.7270/Q2HT2MMT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM21844 (8-[(1R,3aR)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astraea Therapeutics Curated by ChEMBL | Assay Description Binding affinity to human nociceptin opioid receptor | J Med Chem 59: 7011-28 (2016) Article DOI: 10.1021/acs.jmedchem.5b01499 BindingDB Entry DOI: 10.7270/Q2057KDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM21844 (8-[(1R,3aR)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Superiore di Sanit£ Curated by ChEMBL | Assay Description Displacement of [125I]Tyr14-nociceptin from human NOP receptor expressed in human HEK293 cells after 2 hrs by scintillation counting | Eur J Med Chem 46: 1207-21 (2011) Article DOI: 10.1016/j.ejmech.2011.01.040 BindingDB Entry DOI: 10.7270/Q2NK3FBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM21844 (8-[(1R,3aR)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 39 | n/a | n/a | n/a | n/a |
Astraea Therapeutics Curated by ChEMBL | Assay Description Agonist activity at human nociceptin opioid receptor by GTPgamma(35)S binding assay | J Med Chem 59: 7011-28 (2016) Article DOI: 10.1021/acs.jmedchem.5b01499 BindingDB Entry DOI: 10.7270/Q2057KDD | |||||||||||
More data for this Ligand-Target Pair |