BindingDB PrimarySearch

Found 17 hits Enz. Inhib. hit(s) with Target = 'Nociceptin receptor' and Ligand = 'BDBM50106479'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Louisiana State University Curated by PDSP K_i Database									J Pharmacol Exp Ther 314: 652-60 (2005) Article DOI: 10.1124/jpet.105.083436 BindingDB Entry DOI: 10.7270/Q2H41Q0Q
Louisiana State University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Binding affinity to human NOP receptor				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (MOUSE)	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Affinity to nociceptin receptors on mouse forebrain membranes by [3H]NC-NH2 displacement.				J Med Chem 43: 2805-13 (2000) Article DOI: 10.1021/jm990075h BindingDB Entry DOI: 10.7270/Q2028V88
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (MOUSE)	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.912	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of [3H]NC-NH2 binding to mouse forebrain membranes				J Med Chem 44: 3956-64 (2001) Article DOI: 10.1021/jm010221v BindingDB Entry DOI: 10.7270/Q26D5WR4
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.353	n/a	n/a	n/a	n/a	n/a	n/a
Tohoku Pharmaceutical University Curated by ChEMBL					Assay Description Displacement of [3H]-NC from human ORL1 receptor expressing HEK-293 cell membrane				J Med Chem 44: 4015-8 (2001) BindingDB Entry DOI: 10.7270/Q25H7FJJ
Tohoku Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (RAT)	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	575	n/a	n/a	n/a	n/a
University of Chemical Technology and Metallurgy Curated by ChEMBL					Assay Description Activity against LFES-evoked contraction of Wistar rat vas deferens				Bioorg Med Chem Lett 16: 4071-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.086 BindingDB Entry DOI: 10.7270/Q2B85BW5
					More data for this Ligand-Target Pair
Nociceptin receptor (RAT)	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	51	n/a	n/a	n/a	n/a
Bulgarian Academy of Sciences Curated by ChEMBL					Assay Description Activity at Wistar rat NOP receptor assessed as inhibition of low-frequency electrically-stimulated vas deferens contraction				Bioorg Med Chem Lett 23: 4052-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.064 BindingDB Entry DOI: 10.7270/Q2639SNZ
Bulgarian Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.30	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.9b02057 BindingDB Entry DOI: 10.7270/Q23X8B75
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing beta-arrestin2-RGFP protein assessed as induction of beta-a...				Citation and Details Article DOI: 10.1021/acs.jmedchem.9b02057 BindingDB Entry DOI: 10.7270/Q23X8B75
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (RAT)	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	398	n/a	n/a	n/a	n/a
University of Chemical Technology and Metallurgy Curated by ChEMBL					Assay Description Activity against LFES-evoked contraction of Wistar rat vas deferens in presence of naloxone				Bioorg Med Chem Lett 16: 4071-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.086 BindingDB Entry DOI: 10.7270/Q2B85BW5
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.513	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of calcium mobilization by Fluo-4 AM dye based analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02062 BindingDB Entry DOI: 10.7270/Q2KH0S68
TBA					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.82	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.780	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Agonist activity at human NOP receptor by [35S]GTPgammaS binding assay				J Med Chem 51: 4385-7 (2008) Article DOI: 10.1021/jm800394v BindingDB Entry DOI: 10.7270/Q2B56KN8
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (MOUSE)	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay				J Med Chem 53: 8400-8408 (2010) Article DOI: 10.1021/jm101139f BindingDB Entry DOI: 10.7270/Q24Q7V77
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.12	n/a	n/a	n/a	n/a
Tohoku Pharmaceutical University Curated by ChEMBL					Assay Description Efficacy for human ORL1 receptor expressing HEK-293 cells				J Med Chem 44: 4015-8 (2001) BindingDB Entry DOI: 10.7270/Q25H7FJJ
Tohoku Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50106479 (CHEMBL384755 \| FGGFTGARKSARK \| H-FGGFTGARKSARK-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.324	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptor				J Med Chem 44: 3956-64 (2001) Article DOI: 10.1021/jm010221v BindingDB Entry DOI: 10.7270/Q26D5WR4
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair