BindingDB PrimarySearch

Found 15 hits Enz. Inhib. hit(s) with Target = 'Nociceptin receptor' and Ligand = 'BDBM50333104'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Binding affinity to human NOP receptor by radioligand displacement assay				Eur J Med Chem 63: 85-94 (2013) Article DOI: 10.1016/j.ejmech.2013.01.044 BindingDB Entry DOI: 10.7270/Q2JH3NKC
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (MOUSE)	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Affinity to nociceptin receptors on mouse forebrain membranes by [3H]NC-NH2 displacement.				J Med Chem 43: 2805-13 (2000) Article DOI: 10.1021/jm990075h BindingDB Entry DOI: 10.7270/Q2028V88
University of Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Displacement of [3H]nociceptin from recombinant ORL1 receptor expressed in COS7 cells by competitive receptor binding assay				Bioorg Med Chem 17: 7904-8 (2009) Article DOI: 10.1016/j.bmc.2009.10.026 BindingDB Entry DOI: 10.7270/Q28C9X65
Kyushu University Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Binding affinity to ORL1 receptor (unknown origin) by radioligand displacement assay				Bioorg Med Chem 21: 2764-71 (2013) Article DOI: 10.1016/j.bmc.2013.03.016 BindingDB Entry DOI: 10.7270/Q2N87C5Q
Institute of Organic Synthesis Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cells				Bioorg Med Chem 16: 2635-44 (2008) Article DOI: 10.1016/j.bmc.2007.11.043 BindingDB Entry DOI: 10.7270/Q2416XW9
Kyushu University Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Displacement of [3H]nociceptin from recombinant ORL1 receptor expressed in COS7 cells by competitive receptor binding assay				Bioorg Med Chem 17: 7904-8 (2009) Article DOI: 10.1016/j.bmc.2009.10.026 BindingDB Entry DOI: 10.7270/Q28C9X65
Kyushu University Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (RAT)	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]nociceptin from rat ORL1 receptor expressed in african green monkey COS7 cells				Bioorg Med Chem 16: 9261-7 (2008) Article DOI: 10.1016/j.bmc.2008.09.014 BindingDB Entry DOI: 10.7270/Q2MC90XH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method				Bioorg Med Chem 25: 471-482 (2017) Article DOI: 10.1016/j.bmc.2016.11.014 BindingDB Entry DOI: 10.7270/Q2CF9S3S
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Binding affinity to human NOP receptor by radioligand displacement assay				Eur J Med Chem 63: 85-94 (2013) Article DOI: 10.1016/j.ejmech.2013.01.044 BindingDB Entry DOI: 10.7270/Q2JH3NKC
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.91	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Activity at human ORL1-Galpha fusion receptor in COS7 cells assessed as stimulation of [35S]GTP-gamma-S binding				Bioorg Med Chem 16: 2635-44 (2008) Article DOI: 10.1016/j.bmc.2007.11.043 BindingDB Entry DOI: 10.7270/Q2416XW9
Kyushu University Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (RAT)	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Activation of rat ORL1 receptor expressed in african green monkey COS7 cells by [35S]GTPgammaS binding assay				Bioorg Med Chem 16: 9261-7 (2008) Article DOI: 10.1016/j.bmc.2008.09.014 BindingDB Entry DOI: 10.7270/Q2MC90XH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Agonist activity at recombinant ORL1 receptor expressed in COS7 cells assessed as stimulation of GTPgammaS binding				Bioorg Med Chem 17: 7904-8 (2009) Article DOI: 10.1016/j.bmc.2009.10.026 BindingDB Entry DOI: 10.7270/Q28C9X65
Kyushu University Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (MOUSE)	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay				J Med Chem 53: 8400-8408 (2010) Article DOI: 10.1021/jm101139f BindingDB Entry DOI: 10.7270/Q24Q7V77
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.0920	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Binding affinity to recombinant ORL1 receptor expressed in COS7 cells by saturation binding assay				Bioorg Med Chem 17: 7904-8 (2009) Article DOI: 10.1016/j.bmc.2009.10.026 BindingDB Entry DOI: 10.7270/Q28C9X65
Kyushu University Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50333104 (CHEMBL389521 \| H-FGGFTGARKSARKLANQ-NH2 \| N/OFQ-NH2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Agonist activity at recombinant ORL1 receptor expressed in COS7 cells assessed as stimulation of GTPgammaS binding				Bioorg Med Chem 17: 7904-8 (2009) Article DOI: 10.1016/j.bmc.2009.10.026 BindingDB Entry DOI: 10.7270/Q28C9X65
Kyushu University Curated by ChEMBL					More data for this Ligand-Target Pair