Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2' and Ligand = 'BDBM325499'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325499 (US10189845, Example 161 | US10730880, Example 161 ...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@H](O)C1 |r,wU:26.30,wD:24.27,(-1.67,6.5,;-2.44,5.17,;-1.67,3.84,;-.13,3.84,;.64,5.17,;-2.44,2.5,;-1.96,1.04,;-3.21,.13,;-4.45,1.04,;-3.98,2.5,;-3.21,-1.41,;-1.87,-2.18,;-1.87,-3.72,;-3.21,-4.49,;-4.54,-3.72,;-6,-4.19,;-6.91,-2.95,;-6,-1.7,;-4.54,-2.18,;-.54,-4.49,;-.54,-6.03,;.93,-6.5,;1.83,-5.26,;.93,-4.01,;3.32,-4.86,;4.65,-5.63,;5.42,-4.3,;6.91,-3.9,;4.09,-3.53,)| Show InChI InChI=1S/C21H25N7O/c1-3-16(4-2)26-12-15(10-24-26)21-20-5-6-22-28(20)13-19(25-21)14-9-23-27(11-14)17-7-18(29)8-17/h5-6,9-13,16-18,29H,3-4,7-8H2,1-2H3/t17-,18-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325499 (US10189845, Example 161 | US10730880, Example 161 ...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@H](O)C1 |r,wU:26.30,wD:24.27,(-1.67,6.5,;-2.44,5.17,;-1.67,3.84,;-.13,3.84,;.64,5.17,;-2.44,2.5,;-1.96,1.04,;-3.21,.13,;-4.45,1.04,;-3.98,2.5,;-3.21,-1.41,;-1.87,-2.18,;-1.87,-3.72,;-3.21,-4.49,;-4.54,-3.72,;-6,-4.19,;-6.91,-2.95,;-6,-1.7,;-4.54,-2.18,;-.54,-4.49,;-.54,-6.03,;.93,-6.5,;1.83,-5.26,;.93,-4.01,;3.32,-4.86,;4.65,-5.63,;5.42,-4.3,;6.91,-3.9,;4.09,-3.53,)| Show InChI InChI=1S/C21H25N7O/c1-3-16(4-2)26-12-15(10-24-26)21-20-5-6-22-28(20)13-19(25-21)14-9-23-27(11-14)17-7-18(29)8-17/h5-6,9-13,16-18,29H,3-4,7-8H2,1-2H3/t17-,18-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021) BindingDB Entry DOI: 10.7270/Q2T156RN
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325499 (US10189845, Example 161 | US10730880, Example 161 ...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@H](O)C1 |r,wU:26.30,wD:24.27,(-1.67,6.5,;-2.44,5.17,;-1.67,3.84,;-.13,3.84,;.64,5.17,;-2.44,2.5,;-1.96,1.04,;-3.21,.13,;-4.45,1.04,;-3.98,2.5,;-3.21,-1.41,;-1.87,-2.18,;-1.87,-3.72,;-3.21,-4.49,;-4.54,-3.72,;-6,-4.19,;-6.91,-2.95,;-6,-1.7,;-4.54,-2.18,;-.54,-4.49,;-.54,-6.03,;.93,-6.5,;1.83,-5.26,;.93,-4.01,;3.32,-4.86,;4.65,-5.63,;5.42,-4.3,;6.91,-3.9,;4.09,-3.53,)| Show InChI InChI=1S/C21H25N7O/c1-3-16(4-2)26-12-15(10-24-26)21-20-5-6-22-28(20)13-19(25-21)14-9-23-27(11-14)17-7-18(29)8-17/h5-6,9-13,16-18,29H,3-4,7-8H2,1-2H3/t17-,18-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020) BindingDB Entry DOI: 10.7270/Q2CC13R9
					More data for this Ligand-Target Pair