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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Opioid receptors; mu/kappa/delta' and Ligand = 'BDBM199363'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Opioid receptors; mu/kappa/delta


(Homo sapiens (Human))
BDBM199363
PNG
(US9221831, 28)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]1(CC[C@@]35C[C@@H]1CNCc1ccccc1)OC |r,THB:26:25:15.16:22.21|
Show InChI InChI=1/C32H40N2O3/c1-35-25-11-10-23-16-26-30-12-13-32(36-2,24(17-30)19-33-18-21-6-4-3-5-7-21)29-31(30,27(23)28(25)37-29)14-15-34(26)20-22-8-9-22/h3-7,10-11,22,24,26,29,33H,8-9,12-20H2,1-2H3/t24-,26-,29-,30-,31+,32-/s2
PDB

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PC cid
PC sid
UniChem
US Patent
0.0400n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...


US Patent US9221831 (2015)


BindingDB Entry DOI: 10.7270/Q2T72G8M
More data for this
Ligand-Target Pair
Opioid receptors; mu/kappa/delta


(Homo sapiens (Human))
BDBM199363
PNG
(US9221831, 28)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]1(CC[C@@]35C[C@@H]1CNCc1ccccc1)OC |r,THB:26:25:15.16:22.21|
Show InChI InChI=1/C32H40N2O3/c1-35-25-11-10-23-16-26-30-12-13-32(36-2,24(17-30)19-33-18-21-6-4-3-5-7-21)29-31(30,27(23)28(25)37-29)14-15-34(26)20-22-8-9-22/h3-7,10-11,22,24,26,29,33H,8-9,12-20H2,1-2H3/t24-,26-,29-,30-,31+,32-/s2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.42n/an/a7.425



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding final ...


US Patent US9221831 (2015)


BindingDB Entry DOI: 10.7270/Q2T72G8M
More data for this
Ligand-Target Pair