Found 4 hits Enz. Inhib. hit(s) with Target = 'Palmitoleoyl-protein carboxylesterase NOTUM' and Ligand = 'BDBM50144578' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Palmitoleoyl-protein carboxylesterase NOTUM
(Homo sapiens (Human)) | BDBM50144578
(CHEMBL3760062)Show InChI InChI=1S/C13H8ClFO2S/c14-10-5-7(15)4-9-8(10)2-1-6-3-11(13(16)17)18-12(6)9/h3-5H,1-2H2,(H,16,17) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01974 BindingDB Entry DOI: 10.7270/Q2NP28F9 |
More data for this Ligand-Target Pair | |
Palmitoleoyl-protein carboxylesterase NOTUM
(Homo sapiens (Human)) | BDBM50144578
(CHEMBL3760062)Show InChI InChI=1S/C13H8ClFO2S/c14-10-5-7(15)4-9-8(10)2-1-6-3-11(13(16)17)18-12(6)9/h3-5H,1-2H2,(H,16,17) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01974 BindingDB Entry DOI: 10.7270/Q2NP28F9 |
More data for this Ligand-Target Pair | |
Palmitoleoyl-protein carboxylesterase NOTUM
(Mus musculus) | BDBM50144578
(CHEMBL3760062)Show InChI InChI=1S/C13H8ClFO2S/c14-10-5-7(15)4-9-8(10)2-1-6-3-11(13(16)17)18-12(6)9/h3-5H,1-2H2,(H,16,17) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay |
Bioorg Med Chem Lett 26: 1184-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.038 BindingDB Entry DOI: 10.7270/Q2QV3PBN |
More data for this Ligand-Target Pair | |
Palmitoleoyl-protein carboxylesterase NOTUM
(Homo sapiens (Human)) | BDBM50144578
(CHEMBL3760062)Show InChI InChI=1S/C13H8ClFO2S/c14-10-5-7(15)4-9-8(10)2-1-6-3-11(13(16)17)18-12(6)9/h3-5H,1-2H2,(H,16,17) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay |
Bioorg Med Chem Lett 26: 1184-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.038 BindingDB Entry DOI: 10.7270/Q2QV3PBN |
More data for this Ligand-Target Pair | |