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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM125327'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM125327
PNG
(US8772480, 150)
Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(C)c2ccc(cc2)S(C)(=O)=O)cc1F
Show InChI InChI=1S/C24H24FN7O3S/c1-13(15-5-7-18(8-6-15)36(4,33)34)16-9-19(22-29-14(2)30-24(26)32-22)21(27-11-16)31-17-10-20(25)23(35-3)28-12-17/h5-13H,1-4H3,(H,27,31)(H2,26,29,30,32)
PDB
MMDB

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US Patent
1n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...


US Patent US8772480 (2014)


BindingDB Entry DOI: 10.7270/Q2V123FJ
More data for this
Ligand-Target Pair