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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM125361'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM125361
PNG
(US8772480, 191)
Show SMILES Cc1nc(N)nc(n1)-c1cccnc1Nc1ccc(NC(=O)Nc2cccc(F)c2)nc1
Show InChI InChI=1S/C21H18FN9O/c1-12-26-19(31-20(23)27-12)16-6-3-9-24-18(16)28-15-7-8-17(25-11-15)30-21(32)29-14-5-2-4-13(22)10-14/h2-11H,1H3,(H,24,28)(H2,23,26,27,31)(H2,25,29,30,32)
PDB
MMDB

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US Patent
4n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...


US Patent US8772480 (2014)


BindingDB Entry DOI: 10.7270/Q2V123FJ
More data for this
Ligand-Target Pair